The museum opened in the year 2000 and is located in a former Sisters of Mercy convent building, built in 1854. The exhibition is on two floors and includes archaeological objects on loan from the National Museum of Ireland and historical objects with an authentic connection to Eamon de Valera and Daniel O'Connell who both began their political careers in Clare.
It is located in the centre of the town, adjacent to a car coach park. It incorporates Ennis Tourist Office for tourist information about the county and beyond.
The Clare Museum is within a short walking distance of hotels, cafés and restaurant.